2nd International Symposium on Fibromuscular Dysplasia and Related Vascular Diseases


Prof. Andrzej Januszewicz, Prof. Aleksander Prejbisz
Department of Hypertension, Institute of Cardiology, Warsaw, Poland

Prof. Alexandre Persu
Cardiology Department, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

Prof. Heather Gornik
University Hospitals Harrington Heart & Vascular Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio

Day 1, November 5th

08.30–09.00 Opening session
1. Introduction and Welcome (H. Gornik, A. Januszewicz, A. Persu, A. Prejbisz)
2. Address of the Director of the Institute of Cardiology
3. Address of the President of the European Society of Hypertension

09.00–10.30 Registries, networks and databases: current status
Moderators: C. Kępka, H. Górnik, E. Poch
1. The European/International FMD registry and initiative (A. Persu and L. Toubiana)
2. The US Registry for FMD (J. Olin)
3. The ARCADIA-PROFILE French Registry (M. Azizi)
4. The ARCADIA-POL Registry (A. Januszewicz)
5. Discussion

10.30–11.00Coffee break


Renal and visceral FMD

Moderators: A. Lorthioir,A. Prejbisz, A. Klisiewicz
1. Optimal imaging in renal FMD: Doppler duplex vs CT-angiography (A. Januszewicz / A. Prejbisz)
2. RAS, renal hemodynamics and kidney function in FMD (D. van Twist)
3. International Consensus for renal angiography and angioplasty (J. Olin)
4. Renal artery dissections, aneurysms and renal infarctions (L. Amar)
5. Renal FMD and chronic kidney disease (B. Jelakovic)
6. Visceral FMD and aneurysms (P. Van der Niepen)
7. Complications of renal stenting in FMD (J. Kądziela)
8. Discussion



Etiopathology and differential diagnosis of FMD

Moderators: A. Januszewicz, I. Michałowska
1. Impact of smoking on FMD (P. Dobrowolski)
2. Focus on pregnancy-related complications of FMD (M. Pappaccogli)
3. Segmental Arteriolar Mediolysis (SAM); could this be related to FMD? (C. Canning)
4. Vascular Ehlers-Danlos what the FMD expert should know (X. Jeunemaitre)
5. What can the experience of aortic dissection research teach us about how to further study FMD? (J. Froehlich)
6. Are there non-vascular features of FMD? (H. Gornik)
7. FMD – immunological and inflammatory aspects (T. Guzik)


Genomics and proteomic of FMD and SCAD

Moderators: X. Jeunemaitre, J. Froehlich
1. Potential involvement of the TGF-beta pathway in FMD (B. Loeys)
2. Genetics of FMD - US perspective (S. Ganesh)
3. Genetics of FMD and SCAD: European perspective (N. Bouatia-Naji)
4. Rare and recurrent loss-of-function variants of the prostacyclin receptor gene identified in FMD and SCAD (A. Georges)
5. Promises of Proteomics in FMD/ the DEFINE study (J. Kovacic)
6. Discussion

17.00–17.15Coffee break


Cerebrovascular FMD and cervical artery dissection

Moderators: M. Szczerbo-Trojanowska,A. Morganti, D. Gąsecki
1. Management of cerebrovascular FMD (M. Boulanger)
2. Characteristics of cerebrovascular FMD in ARCADIA-POL (E. Warchoł-Celińska and M. Pappaccogli)
3. How frequent is FMD among patients with carotid dissection? (P. Talarowska)

Day 2, November 6th

9.00–10.30 Spontaneous coronary artery dissection (SCAD)
Moderators: D. Adlam, A. Witkowski, E. Florczak
1. Comparing US and European SCAD consensus documents (A. Maas)
2. Prevalence of remote arteriopathies including FMD in SCAD. Lessons from the UK registry (D. Adlam)
3. Is coronary FMD the cause of SCAD? Lessons from the Canadian registry (J. Saw)
4. Long term follow-up for SCAD with and without FMD - to image or not to image? Recommendations from the US registry (E. Kim)
5. Polish SCAD research program (J. Kadziela)
6. Discussion

10.30–12.00 Paediatric FMD
Moderators: A. Morganti, M. Litwin, K. Jóźwik-Plebanek
1. Main differences between adult and paediatric (A. Persu)
2. Renal artery FMD and mid-aortic syndrome in children (K. Tullus)
3. Revascularization in renal arteries of children with FMD (P. Salice)
4. Pediatric FMD: the Warsaw experience (M.Litwin)
5. Discussion


12.45–13.45 Novel approaches and new directions in FMD research
Moderators: P. Boutouyrie, J. Olin, M. Kruk
1. Ultra-high frequency US/FUCHSIA study (R.M. Bruno)
2. The case for narrow arteries in patients with FMD (E. Warchoł-Celińska)
3. Arterial dissections due to quinolones: a clue to FMD susceptibility? (M. Azizi)
4. Myofibromatosis, cerebral aneurysms and PDGFRB mutations- a link with FMD? (J.-B. Demoulin)
5. Discussion

13.45–15.00 International collaborations and awareness efforts
Moderators: M. Azizi, A. Persu, J.Olin, A. Januszewicz
1. The International FMD Consensus (H. Gornik / A. Persu)
2. The Fibromuscular Dysplasia Society of America (FMDSA) (P. Mace)
3. The European patient network (C. Jamison)
4. The UK –Ireland patient association (T. Chrysochou)
5.Discussion: How can we build future capacity for patient-centered FMD clinical effectiveness research (H. Gornik and conference attendees)

15.00–15.30 General discussion and wrap-up
Moderators: H. Gornik, A. Januszewicz, A. Persu, A. Prejbisz

16.30–18.00 Meeting for FMD and SCAD patients
• Introduction (A. Januszewicz, H. Gornik, A. Persu)
• Current research and new finding in SCAD and FMD (J. Kądziela, K. Jóźwik-Plebanek
• Meeting with representatives of FMD patient associations - presentation of the goals and principles of operation of organizations
• P. Mace (Fibromuscular Dysplasia Society of America)
• C. Jamison (Fibromuscular Dysplasia Patient Association in Belgium)
• C. Chrysochou (Fibromuscular Dysplasia Society of UK and Ireland)
• Establishment of the Polish Association of Patients with Fibromuscular Dysplasia and After Spontaneous Coronary Artery Dissection
• Conclusions